Subject code BT3751 deals with the semester VII subject syllabus from Anna University 2021 relevant to affiliated institutions. In this article, we would like to introduce the syllabus of the BT3751 – Downstream Processing in B.Tech Biotechnology and Biochemical Engineering.
We like to provide the BT3751 – Downstream Processing syllabus for students to perform well academically. This article will assist the students in getting the required syllabus for each unit with different concepts. We include expert textbooks and references for students to avoid confusion when reading books. The following links will help you to select the subject you want to read. Hope this information is useful. Don’t forget to share this information with your friends.
If you want to know more about the syllabus of B.Tech Biotechnology and Biochemical Engineering Syllabus connected to an affiliated institution’s four-year undergraduate degree program. We provide you with a detailed Year-wise, semester-wise, and Subject-wise syllabus in the following link B.Tech Biotechnology and Biochemical Engineering Syllabus Anna University Regulation 2021.
Aim Of Concept:
To enable the students to
- Understand the methods to obtain pure proteins, enzymes and in general about product development R & D
- Have depth knowledge and hands on experience with on Downstream processes required in multi-factorial manufacturing environment in a structured and logical fashion
BT3751 – Downstream Processing Syllabus
Unit I: Introduction
Introduction to downstream processing, principles, characteristics of bio-molecules and bioprocesses. Cell disruption for product release – mechanical, enzymatic and chemical methods. Pre-treatment and stabilisation of bio-products.
Unit II: Physical Methods Of Separation
Unit operations for solid-liquid separation – filtration and centrifugation.
Unit III: Isolation Of Products
Adsorption, liquid-liquid extraction, aqueous two-phase extraction, membrane separation – ultra filtration and reverse osmosis, dialysis, precipitation of proteins by different methods.
Unit IV: Product Purification
Chromatography – principles, instruments and practice, adsorption, reverse phase, ion exchange, size exclusion, hydrophobic interaction, bio-affinity and pseudo affinity chromatographic techniques.
Unit V: Final Product Formulation And Finishing Operations
Crystallization, drying and lyophilization in final product formulation
Text Books:
- Belter, P.A., E.L. Cussler and Wei-Houhu “Bioseparations – Downstream Processing for Biotechnology”, John Wiley, 1988.
- Nooralabettu Krishna Prasad., Downstream Process Technology: A New Horizon in Biotechnology, Prentice Hall India,2010.
- Sivasankar, B. “Bioseparations: Principles and Techniques”. PHI, 2006.
References:
- Raja Ghosh “Principles of Bioseparations Engineering”. World Scientific, 2006
- Michael R.Ladisch Bioseparations Engineering: Principles, practice and Economics, Wiley Interscience, 1st Edition,2001.
- Product Recovery in Bioprocess Technology”. (BIOTOL – Biotechnology by Open Learning Series). Butterworth – Heinmann / Elsevier, 2004.
Related Posts On Semester – VII:
- GE3791 – Human Values and Ethics
- BT3761 – Downstream Laboratory
- BI3711 – Industrial Training/Internship II
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